SKU-Pack Size | Availability | Size | Price | |
EAB22147-100UL | In Stock | 100ul | ¥2290.00 |
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北京美瑞克生物科技有限公司 | Phone: +86 010-62890160 / 13691184142(微信同号) |
2 / F, 128 malianwa North Road, Haidian District, | E-mail: mrkbio@163.com | |
China | Beijing China | Website: www.mrkbio.com |
Product Information | |
Applications | WB, IP, IHC-P, IF/ICC |
Species Reactivity | Human, Mouse, Rat |
Host / Isotype | Rabbit IgG |
Clonality | Monoclonal |
Applications Dilutions | WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 IF/ICC=1:100-500 |
MW (kDa) | 39/37 |
Conjugate | Unconjugate |
Specificity | Phospho-MKK3 (Ser189)/MKK6 (Ser207) Rabbit Monoclonal Antibody recognizes endogenous levels of MKK3 and MKK6 proteins only when phosphorylated at Ser189 (MKK3) or Ser207 (MKK6). |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
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Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
Product Bioinformatics | |
Synonym(s) | Mitogen-activated protein kinase kinase 3; Mitogen-activated protein kinase kinase 6; MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2; MEK6; MKK6; CRCMSL; MAPKK6; PRKMK6; SAPKK3; SAPKK-3; MAP2K3; MAP2K6 |
Gene Aliases | MAP2K3/MAP2K6 |
UniProt ID | |
Entrez Gene ID |
Product Description | |
MKK3/MKK6 is a protein that plays a crucial role in the MAPK signaling pathway, specifically in the activation of p38 MAP kinase and JNK MAP kinases, which are essential for cellular responses to stress and inflammation. MKK3/MKK6 recognizes a protein vital for regulating various physiological processes, including cell differentiation, proliferation, and apoptosis. Dysregulation of this pathway can lead to various diseases, including cancer and inflammatory disorders, making MKK3/MKK6 a significant target for therapeutic intervention. Understanding MKK3/MKK6 interactions with other proteins in the MAPK pathway can provide insights into regulatory mechanisms and potential roles in disease progression. |
Product Image Gallery | |
![]() Western blot analysis of extracts on Hela cells treated with TPA, using Phospho-MKK3 (Ser189)/MKK6 (Ser207) Rabbit Monoclonal Antibody (EAB22147) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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Specific Protocols | |