Recombinant Antibodies - Phospho-MKK3 (Ser189)/MKK6 (Ser207) Rabbit Monoclonal Antibody

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Phospho-MKK3 (Ser189)/MKK6 (Ser207) Rabbit Monoclonal Antibody

Catalog #：EAB22147

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB22147-100UL	In Stock	100ul	$343.50

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	EbioCell	Phone：(540) 808-3925
	Imperial Business Park 4819 Emperor Boulevard,	E-mail：order@ebiocell.com
Canada	Suite 408 Durham, NC 27703, USA	Web：www.ebiocell.com

Product Information
Applications	WB, IP, IHC-P, IF/ICC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IP=1:10-100 IHC-P=1:50-200　 IF/ICC=1:100-500
MW (kDa)	39/37
Conjugate	Unconjugate
Specificity	Phospho-MKK3 (Ser189)/MKK6 (Ser207) Rabbit Monoclonal Antibody recognizes endogenous levels of MKK3 and MKK6 proteins only when phosphorylated at Ser189 (MKK3) or Ser207 (MKK6).
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Mitogen-activated protein kinase kinase 3; Mitogen-activated protein kinase kinase 6; MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2; MEK6; MKK6; CRCMSL; MAPKK6; PRKMK6; SAPKK3; SAPKK-3; MAP2K3; MAP2K6
Gene Aliases	MAP2K3/MAP2K6
UniProt ID	P46734, P52564
Entrez Gene ID	5606, 5608

Product Description

MKK3/MKK6 is a protein that plays a crucial role in the MAPK signaling pathway, specifically in the activation of p38 MAP kinase and JNK MAP kinases, which are essential for cellular responses to stress and inflammation. MKK3/MKK6 recognizes a protein vital for regulating various physiological processes, including cell differentiation, proliferation, and apoptosis. Dysregulation of this pathway can lead to various diseases, including cancer and inflammatory disorders, making MKK3/MKK6 a significant target for therapeutic intervention. Understanding MKK3/MKK6 interactions with other proteins in the MAPK pathway can provide insights into regulatory mechanisms and potential roles in disease progression.

Product Image Gallery
Western blot analysis of extracts on Hela cells treated with TPA, using Phospho-MKK3 (Ser189)/MKK6 (Ser207) Rabbit Monoclonal Antibody (EAB22147) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol