Recombinant Antibodies - SREBP-1 Rabbit Monoclonal antibody

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SREBP-1 Rabbit Monoclonal antibody

Catalog #：EAB22796

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB22796-100UL	In Stock	100ul	€297.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

Please select the country you are in to find your local distributor.

	Betaclonal	Phone：+34 (0)91 471 6763
	29/1 Lomonosovsky Pr,	E-mail：tech@betaclonal.com
Spain	Madrid, Spain	Web：www.betaclonal.com

Product Information
Applications	WB, IHC-P, IF/ICC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:1000-5000　 IHC-P=1:100-500　 IF/ICC=1:100-500
MW (kDa)	122
Conjugate	Unconjugate
Specificity	SREBP-1 Rabbit Monoclonal antibody detects endogenous levels of SREBP-1 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Sterol regulatory element binding transcription factor 1; HMD; IFAP2; SREBP1; bHLHd1; SREBF1
Gene Aliases	SREBF1
UniProt ID	P36956
Entrez Gene ID	6720

Product Description

SREBP-1 also known as SREBF1 is a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1). SREBP-1 plays a crucial role in lipid metabolism by regulating the expression of genes involved in cholesterol and fatty acid synthesis. SREBP-1 is primarily located in the endoplasmic reticulum and the nuclear envelope, where SREBP-1 exists as a precursor form. Upon sterol depletion, SREBP-1 undergoes proteolytic cleavage, releasing a soluble fragment that translocates to the nucleus to activate transcription of target genes, thereby enhancing the uptake of low-density lipoprotein (LDL) and promoting lipid biosynthesis. The regulation of SREBP-1 is vital for maintaining cellular lipid homeostasis, as excessive cholesterol accumulation can lead to various metabolic disorders.

Product Image Gallery
Western blot analysis of extracts on Hela, A549 cells, using SREBP-1 Rabbit Monoclonal antibody (EAB22796) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol