P04628

Wnt1 is a member of the highly conserved Wnt gene family. Wnt1 plays a crucial role in regulating cellular growth and differentiation, making Wnt1 vital for various developmental processes. Wnt1 is a cysteine-rich secreted glycoprotein that associates with cell membranes and is essential for normal development of the embryonic nervous system. Wnt1 expression is typically restricted to the embryonic neural tube and adult spermatids, highlighting Wnt1′s importance in developmental biology. Aberrant Wnt-1 expression in mammary tissue has been linked to hyperplasia and tumorigenic progression, underscoring Wnt1′s role in cancer biology. Additionally, Wnt1 interacts with β-catenin, a key player in cellular adhesion and a downstream target in the Wnt signaling pathway, which further emphasizes Wnt1′s significance in both normal and pathological processes.