Q07869

PPARα also known as PPARalpha, PPARA is a pivotal nuclear hormone receptor that plays a significant role in regulating fatty acid metabolism, lipid homeostasis, and overall energy balance, making PPARα essential for maintaining metabolic health. By forming heterodimers with retinoid X receptors (RXRs), PPARα binds to specific PPAR-response elements (PPREs) in DNA, thereby modulating the transcription of genes involved in lipid metabolism and energy utilization. PPARα functionality is crucial in primary hepatocytes, where PPARα governs the expression of proteins necessary for fatty acid oxidation and overall metabolic processes. Additionally, PPARα interacts with other nuclear receptors such as LXRα and thyroid receptors, which can act as antagonists to PPARα binding with RXRα at PPREs, highlighting the intricate regulatory mechanisms governing lipid metabolism.