P09917

5-lipoxygenase/5-LO plays a crucial role in the biosynthesis of leukotrienes, which are lipid mediators involved in inflammatory responses, particularly in conditions such as asthma and allergic reactions. 5-LO catalyzes the initial steps in the conversion of arachidonic acid into leukotrienes, which induce bronchoconstriction and increase vascular permeability, contributing to the pathophysiology of various inflammatory diseases. 5-LO localization within cells varies depending on cell type and activation state. In activated polymorphonuclear leukocytes, 5-LO translocates from the cytosol to the nuclear envelope in a calcium-dependent manner, while in alveolar macrophages, 5-LO predominantly resides in the nucleus. Upon activation, intranuclear 5-LO associates with the nuclear membrane, a process influenced by interactions with specific signaling molecules, phosphorylation events, and a unique nuclear localization signal encoded at the amino terminus.