Recombinant Antibodies - NumA Rabbit Monoclonal Antibody

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NumA Rabbit Monoclonal Antibody

Catalog #：EAB21764

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21764-100UL	In Stock	100ul	$343.50

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email us at info@ebiocell.com

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	EbioCell	Phone：(540) 808-3925
	Imperial Business Park 4819 Emperor Boulevard,	E-mail：order@ebiocell.com
United States	Suite 408 Durham, NC 27703, USA	Web：www.ebiocell.com

Product Information
Applications	WB, IHC-P, IF/ICC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-200　 IF/ICC=1:50-200
MW (kDa)	238
Conjugate	Unconjugate
Specificity	NumA Rabbit Monoclonal Antibody detects endogenous levels of NumA protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Nuclear mitotic apparatus protein 1; NUMA; NMP-22; NUMA1
Gene Aliases	NUMA1
UniProt ID	Q14980
Entrez Gene ID	4926

Product Description

NumA also known as NumA1 plays a critical role in organizing and stabilizing spindle poles during mitosis, which is essential for accurate chromosome segregation. Mapping to chromosome 11q13, NuMA gene encodes a noncentrosomal protein that binds to microtubules through its carboxyl terminal region, facilitating bipolar spindle formation by aggregating microtubules and interacting with motor proteins. This function is vital for maintaining genomic stability, as errors in spindle assembly can lead to aneuploidy and contribute to tumorigenesis. NuMA protein is predominantly localized to the spindle apparatus during mitosis, yet also appears in the nucleus and cytoplasm of post-mitotic neurons, indicating diverse roles in different cell types.

Product Image Gallery
Western blot analysis of extracts on Hela, MCF7, SH-SY5Y cells, using NumA Rabbit Monoclonal Antibody (EAB21764) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol