Monoclonal Antibodies - CDK4 Mouse Monoclonal Antibody

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CDK4 Mouse Monoclonal Antibody

Catalog #：EAB21265

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21265-100UL	In Stock	100ul	€258.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	SBT BioChem Srl	Phone：+39 05 7156 8147
	Via Ponte di Bagnolo, 811 Bologna,	E-mail：info@sbtbiochem.it
Italy	Italy	Web：www.sbtbiochem.it

Product Information
Applications	WB, IHC-P, FC, ELISA
Species Reactivity	Human, Mouse
Host / Isotype	Mouse IgG2a
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:100-500　 FC=1:50-200
MW (kDa)	34
Conjugate	Unconjugate
Specificity	CDK4 Mouse Monoclonal Antibody detects endogenous levels of CDK4 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Cyclin dependent kinase 4; CMM3; PSK-J3; CDK4
Gene Aliases	CDK4
UniProt ID	P11802
Entrez Gene ID	1019

Product Description

CDK4 is a vital member of the cyclin-dependent kinase family, playing a crucial role in regulating cell cycle progression by partnering with D-type cyclins to control cell growth during the G1 phase. The function of CDK4 is essential for the phosphorylation of key substrates that drive the cell cycle forward, making CDK4 a significant focus in cancer research and studies of cellular proliferation. The activity of CDK4 is modulated through interaction with cyclins, which enhance kinase activity, and inhibitors like p16, which suppress function. Additionally, the activation of CDK4-cyclin complexes involves phosphorylation by Cdk-activating proteins (CAK), highlighting the sophisticated regulatory mechanisms governing cell cycle progression.

Product Image Gallery
Western blot analysis of extracts on NIH/3T3, COS7 cells, using CDK4 Mouse Monoclonal Antibody (EAB21265) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution. Immunohistochemical analysis of paraffin-embedded Human kidney cancer tissue, using CDK4 Mouse Monoclonal Antibody (EAB21265) at 1:200 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol