Q05513

PKCζ also known as PKC zeta, PRKCZ is an atypical member of the protein kinase C family, playing a crucial role in various cellular processes such as cell growth, differentiation, survival, gene expression, and membrane function. Unlike conventional PKCs, PKCζ activation is independent of calcium and diacylglycerol (DAG), allowing unique function within signaling pathways. PKCζ is involved in the regulation of NF-κB activation, insulin signaling, cell polarity, and the PI3K/Akt pathway, making PKCζ significant in understanding diseases like diabetes, cancer, and immune disorders. PKCζ′s involvement in cell survival and proliferation underscores PKCζ′s importance as a potential therapeutic target.