Monoclonal Antibodies - FGFR1OP Mouse Monoclonal Antibody

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FGFR1OP Mouse Monoclonal Antibody

Catalog #：EAB22815

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB22815-100UL	In Stock	100ul	€336.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	SBT BioChem Srl	Phone：+39 05 7156 8147
	Via Ponte di Bagnolo, 811 Bologna,	E-mail：info@sbtbiochem.it
Italy	Italy	Web：www.sbtbiochem.it

Product Information
Applications	WB, IF/ICC, ELISA
Species Reactivity	Human
Host / Isotype	Mouse IgG1
Clonality	Monoclonal
Applications Dilutions	WB=1:5000-20000　　 IF/ICC=1:500-2000
MW (kDa)	43
Conjugate	Unconjugate
Specificity	FGFR1OP Mouse Monoclonal Antibody detects endogenous levels of FGFR1OP protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Centrosomal protein 43; FGFR1 oncogene partner; FOP; FGFR1OP; CEP43
Gene Aliases	CEP43
UniProt ID	O95684
Entrez Gene ID	11116

Product Description

FGFR1OP(FGFR1 oncogene partner) also known as FOP, CEP43 is a 399 amino acid protein that plays a crucial role in cellular organization by localizing to the centrosome, where FGFR1OP is essential for anchoring microtubules. This localization is vital for maintaining proper cell division and ensuring mitotic spindle stability, which is critical for accurate chromosome segregation during cell division. FGFR1OP is expressed ubiquitously, with highest levels found in kidney, heart, muscle, colon, liver, testis, and pancreas, and functions as a homodimer that interacts with proteins such as EB1 and CEP350. Chromosomal aberrations involving FGFR1OP have been linked to stem cell myeloproliferative disorder development, a condition characterized by eosinophilia and myeloid hyperplasia that can progress to acute myeloid leukemia. FGFR1OP is expressed as multiple isoforms due to alternative splicing, which may contribute to diverse functional roles in cellular processes.

Product Image Gallery
Western blot analysis of extracts on Hela, U2OS, HEK293, K562 cells, using Phospho-Mnk1 (Thr255) Rabbit Polyclonal Antibody (EAB22815) at 1:10000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol