Monoclonal Antibodies - Dnmt1 Mouse Monoclonal Antibody

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Dnmt1 Mouse Monoclonal Antibody

Catalog #：EAB21685

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21685-100UL	In Stock	100ul	€258.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	SBT BioChem Srl	Phone：+39 05 7156 8147
	Via Ponte di Bagnolo, 811 Bologna,	E-mail：info@sbtbiochem.it
Italy	Italy	Web：www.sbtbiochem.it

Product Information
Applications	WB, IHC-P, ELISA
Species Reactivity	Human, Monkey
Host / Isotype	Mouse IgG1
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:100-500
MW (kDa)	183
Conjugate	Unconjugate
Specificity	Dnmt1 Mouse Monoclonal Antibody detects endogenous levels of Dnmt1 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	DNA methyltransferase 1; AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI; DNMT1
Gene Aliases	DNMT1
UniProt ID	P26358
Entrez Gene ID	1786

Product Description

Dnmt1 is an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. Dnmt1 is primarily located in the nucleus, where Dnmt1 interacts with hemimethylated DNA to ensure faithful transmission of epigenetic information during DNA replication. The ability of Dnmt1 to recognize and bind to hemimethylated sites is vital for preserving methylation status of genes, thereby influencing developmental processes and cellular identity. Dysregulation of Dnmt1 has been implicated in various diseases, including cancer, making Dnmt1 a significant target for research into epigenetic therapies.

Product Image Gallery
Western blot analysis of extracts on HCT116, Jurkat cells, using Dnmt1 Mouse Monoclonal Antibody (EAB21685) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution. Immunohistochemical analysis of paraffin-embedded Human rectum cancer tissue, using Dnmt1 Mouse Monoclonal Antibody (EAB21685) at 1:200 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol