Q9NY61

AATF(Apoptosis-antagonizing transcription factor) also known as Che-1 is a widely expressed nuclear protein that belongs to the AATF family. Hyperphosphorylated during the G1/S phase transition, AATF may function as a general inhibitor of the histone deacetylase HDAC1. AATF binding to the pocket region of Rb may displace HDAC1 from Rb/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Displacement of HDAC1 from Sp1 bound to the p21 promoter leads to increased expression of AATF.