P35461

Ly-6G (Lymphocyte antigen 6G) belongs to the Ly-6 family of glycosyl-phosphatidylinositol (GPI)-linked proteins. Ly-6 family members share amino acid homology throughout a distinctive cysteine rich protein domain that incorporates O-linked carbohydrates. Murine Ly-6 molecules have unique patterns of tissue expression during hematopoiesis from multipotential stem cells to lineage committed precursor cells, and on specific leukocyte subpopulations in the peripheral lymphoid tissues. Ly-6G contains one UPAR/Ly6 domain and is expressed almost exclusively on neutrophils localizing to the cell membrane. Ly-6G together with Ly-6C make up the Gr-1 antigen. The Gr-1 antigen is ex- pressed on monocytes, neutrophils and a subset of macrophages, plasmacytoid dendritic cells and T cells. Cells expressing Gr-1 may play a role in the suppression of antitumor and T cell responses. Ly-6G is commonly used as a surface marker for neutrophils.