Q9H6W3

NO66 also known as C14orf169, RIOX1 is a 641 amino acid protein that localizes to nucleoplasmic foci and nucleoli, with specific localization to a granular part of the nucleolus. Expressed throughout the body, NO66 is thought to play a role in the remodeling of certain heterochromatic regions, as well as in the synthesis of the large ribosomal subunit, suggesting involvement in replication-related events. NO66 contains one JmjC domain, two putative nuclear localization signals and several potential phosphorylation sites. Immunohistochemical analysis indicates that NO66 localizes to different subnuclear compartments in different cell lines. Homologs of NO66 have been detected in cell lines from a variety of species. NO66 may be a novel therapeutic target oncogene for lung cancer.