Recombinant Antibodies - ALKBH1 Rabbit Monoclonal Antibody

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ALKBH1 Rabbit Monoclonal Antibody

Catalog #：EAB22448

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB22448-100UL	In Stock	100ul	€297.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	SBT BioChem Srl	Phone：+39 05 7156 8147
	Via Ponte di Bagnolo, 811 Bologna,	E-mail：info@sbtbiochem.it
Italy	Italy	Web：www.sbtbiochem.it

Product Information
Applications	WB, IHC-P
Species Reactivity	Human, Mouse
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-200
MW (kDa)	44
Conjugate	Unconjugate
Specificity	ALKBH1 Rabbit Monoclonal Antibody detects endogenous levels of ALKBH1 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	AlkB homolog 1, histone H2A dioxygenase; ABH; ABH1; alkB; hABH; ALKBH; ALKBH1
Gene Aliases	ALKBH1
UniProt ID	Q13686
Entrez Gene ID	8846

Product Description

ALKBH1 also known as ABH1, ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKBH1 plays a role in resistance to anti-cancer drugs which attempt to damage tumor DNA. Escherichia coli ALKBH1 protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.

Product Image Gallery
Western blot analysis of extracts on Hela, MCF7, HepG2, Jurkat cells, using ALKBH1 Rabbit Monoclonal Antibody (EAB22448) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol