P05937

Calbindin also known as Calbindin D28K, CALB1, D-28K is a 261 amino acid protein with six EF-hand domains, four of which are active calcium-binding domains. Expressed in brain, ovary, uterus, testis, pancreas, liver, kidney and intestine, Calbindin acts as a calcium-buffering agent and alters the activity of the plasma membrane ATPase. In neuronal cells, Calbindin modulates calcium channel activity, calcium transients and intrinsic neuronal firing activity. Also, Calbindin has been implicated to play a role in apoptosis and microtubule function.