Polyclonal Antibodies - MGEA5 Rabbit Polyclonal Antibody

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MGEA5 Rabbit Polyclonal Antibody

Catalog #：EAB11477

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB11477-30UL	In Stock	30ul	€115.70
EAB11477-100UL	In Stock	100ul	€258.70
EAB11477-200UL	In Stock	200ul	€440.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	SBT BioChem Srl	Phone：+39 05 7156 8147
	Via Ponte di Bagnolo, 811 Bologna,	E-mail：info@sbtbiochem.it
Italy	Italy	Web：www.sbtbiochem.it

Product Information
Applications	WB
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000
MW (kDa)	103
Conjugate	Unconjugate
Specificity	MGEA5 Rabbit Polyclonal Antibody detects endogenous levels of MGEA5 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	O-GlcNAcase; MEA5; MGEA5; NCOAT; HEXC; OGA
Gene Aliases	OGA
UniProt ID	O60502
Entrez Gene ID	10724

Product Description

MGEA5 also known as NCOAT, HEXC, MEA5, OGA is a bifunctional enzyme that functions as both a β-hexosaminidase and a histone acetyltransferase. The enzymatic activity of NCOAT is optimal at a slightly acidic pH of 5.7-7 and NCOAT function is competitively inhibited by free N-acetylglucosamine. Due to alternative splicing events, NCOAT is expressed as three isoforms. Isoform 1 localizes to the cytoplasm, while isoform 3 localizes to the nucleus. Expressed ubiquitously with highest expression in placenta, brain and pancreas, NCOAT functions as a glycosidase that catalyzes the cleavage of O-GlcNAc residues from GlcNAc-modified proteins. In addition, NCOAT acetylates specific residues on Histone H3 and Histone H4, suggesting an important role in the histone code.

Product Image Gallery
Western blot analysis of extracts on HepG2 cells, using MGEA5 Rabbit Polyclonal Antibody (EAB11477) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol