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BAG6 Rabbit Polyclonal Antibody
Catalog #:EAB12046
  SKU-Pack Size Availability Size Price
EAB12046-30UL In Stock 30ul $133.50
EAB12046-100UL In Stock 100ul $298.50
EAB12046-200UL In Stock 200ul $508.50
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Product Information
Applications WB
Species Reactivity Human, Mouse, Rat
Host / Isotype Rabbit IgG
Clonality Polyclonal
Applications Dilutions WB=1:500-2000
MW (kDa) 119
Conjugate Unconjugate
Specificity BAG6 Rabbit Polyclonal Antibody detects endogenous levels of BAG6 protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin
IF
-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish
Hr
-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) BAG cochaperone 6; G3; BAT3; BAG-6; D6S52E; BAG6
Gene Aliases BAG6
UniProt ID

P46379

Entrez Gene ID

7917

Product Description

BAG6 also known as BAT3 (HLA-B associated transcript 3), G3, scythe, D6S52E is a proline-rich nuclear protein with an important role as an apoptotic regulator. BAT3 contains one ubiquitin-like domain at its N-terminus and two nuclear localization signals at its C-terminus. Specifically, BAT3 interacts with and stabilizes AIF (apoptosis inducing factor), thereby sensitizing the cell to apoptosis mediated by endoplasmic reticulum (ER) stress. Upon ricin treatment, BAT3 is cleaved by caspase-3 and its C-terminal fragment displays pro-apoptotic activities. The apoptotic activities executed include nuclear condensation, phosphatidlyserine externalization, cell rounding and shrinkage. Mice that are deficient in BAT3 exhibit pronounced defects in lung, brain and kidney development and in the regulation of proliferation and apoptosis. These defects ultimately result in perinatal or midgestational lethality.  

Product Image Gallery
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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