Monoclonal Antibodies - BNIP3 Mouse Monoclonal Antibody

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BNIP3 Mouse Monoclonal Antibody

Catalog #：EAB22482

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB22482-100UL	In Stock	100ul	€258.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	Betaclonal	Phone：+34 (0)91 471 6763
	29/1 Lomonosovsky Pr,	E-mail：tech@betaclonal.com
Spain	Madrid, Spain	Web：www.betaclonal.com

Product Information
Applications	IHC-P, IF/ICC, FC, ELISA
Species Reactivity	Human
Host / Isotype	Mouse IgG2a
Clonality	Monoclonal
Applications Dilutions	IHC-P=1:100-500　 IF/ICC=1:100-500 FC=1:50-200
MW (kDa)	22
Conjugate	Unconjugate
Specificity	BNIP3 Mouse Monoclonal Antibody detects endogenous levels of BNIP3 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	BCL2 interacting protein 3; NIP3; HABON; BNIP3
Gene Aliases	BNIP3
UniProt ID	Q12983
Entrez Gene ID	664

Product Description

BNIP3 (also designated NIP3) is a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. The adenovirus E1B protein is a viral homolog of the Bcl-2 family of proteins that are involved in regulating cell death. A family of interacting proteins, which are designated Nip or Bnip and include BNIP-1, BNIP-2, BNIP-3 and Nix, associate with both the E1B protein and Bcl-2 proteins to mediate apoptotic signaling. BNIP-3 preferentially binds to Bcl-xL and induces apoptosis by suppressing the anti-apoptosis activity of Bcl-xL.

Product Image Gallery
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue, using BNIP3 Mouse Monoclonal Antibody (EAB22482) at 1:200 dilution. Immunofluorescence analysis of Hela cell, using BNIP3 Mouse Monoclonal Antibody (EAB22482) at 1:200 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol