Bif-1 also known as Endophilin B1, SH3GLB1 is a member of the endophilin family, which plays a crucial role in maintaining mitochondrial morphology and regulating the dynamics of the outer mitochondrial membrane, which is essential for cellular energy production and apoptosis regulation. The N-terminal domain of Bif-1 exhibits significant similarity to the lipid-binding and -modifying domain of class A Endophilins, highlighting involvement in lipid metabolism and membrane dynamics. Additionally, Bif-1′s interaction with other proteins, such as Amphiphysin and Dynamin, underscores importance in presynaptic vesicle trafficking at nerve terminals, a process vital for neurotransmitter release and synaptic plasticity.