P27824 

Calnexin also known as CNX, IP90, CANX is a member of the calnexin family of molecular chaperones. As a type I integral membrane protein, Calnexin plays a crucial role in the quality control system of the ER by interacting with newly synthesized N-linked glycoproteins, ensuring their proper folding and assembly. This function is important because it prevents the accumulation of misfolded proteins, which can lead to cellular stress and diseases such as neurodegeneration. Calnexin binds to monoglucosylated glycoproteins, retaining them in the ER until they achieve their correct conformation. By facilitating the maturation of glycoproteins, Calnexin maintains protein homeostasis within the cell.