Annexin A6 also known as Annexin VI, ANXA6 is a member of the annexin family of calcium-binding proteins, which plays crucial roles in cellular processes such as ion flux, endocytosis, exocytosis, and cellular adhesion. Annexin A6 is characterized by a conserved core domain that binds to phospholipids in a calcium-dependent manner, along with a unique amino-terminal region that may provide binding specificity. Furthermore, growth-dependent post-translational modifications of Annexin A6 are essential for proper sub-cellular localization, which is critical for function in cellular signaling and membrane dynamics.Annexin VI interactions with various cellular components underscore importance in maintaining cellular homeostasis and responding to stress signals, making Annexin A6 a valuable target for research in cancer and muscle diseases.