TrkC also known as NTRK3 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkC plays a crucial role in the nervous system as a receptor for neurotrophin-3 (NT-3), which is essential for the survival and differentiation of neurons. TrkC is predominantly expressed in nervous tissue, and activation leads to phosphorylation of tyrosine residues, triggering downstream signaling pathways that promote neuronal growth and survival. Notably, TrkC undergoes alternative splicing, resulting in four isoforms, each with distinct structural features that may influence functional properties and interactions with NT-3. Understanding specific interactions and signaling mechanisms of TrkC is vital for elucidating its role in neurodevelopment and potential implications in neurodegenerative diseases.