P-Selectin also designated CD62P, GMP-140, SELP is a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. P-Selectin plays a crucial role in the inflammatory response by mediating the adhesion of leukocytes to activated endothelial cells and platelets, which is essential for the recruitment of immune cells to sites of injury or infection. P-Selectin is primarily located on the surface of activated platelets and endothelial cells, where P-Selectin facilitates the rolling and adhesion of leukocytes, a critical step in the immune response. Proper functioning of P-Selectin is vital for maintaining vascular integrity and ensuring effective immune surveillance, making P-Selectin a significant target for research in inflammation and cardiovascular diseases.