P25103

NK-1R also designated TACR1, NK1R, SPR, Substance-P Receptor, NK-1 Receptor, TAC1R, NKIR, or neurokinin 1 receptor is a member of a class of tachykinin receptors which also includes the NK-2 receptor and the NK-3 receptor. Substance P receptors bind to tachykinin peptides, including substance P, substance K and neuromedin K. NK-1R is likely to be involved in nociceptive transmission, basal ganglia function or anxiety and depression. NK-1R is expressed in a high proportion of spinothalmic and spinobranchial neurons located in lamina 1. NK-1R neurons in the dorsal horn of the spinal cord may play a role in chronic neuropathic and inflammatory pain. Ligand-induced internalization of NK-1R into early endosomes deplete the cell surface of these receptors. This internalization may be involved in a down-regulation response of a cell to substance P.