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NK-R1 Rabbit Polyclonal Antibody
Catalog #£ºEAB11189
  SKU-Pack Size Availability Size Price
EAB11189-30UL In Stock 30ul €115.70
EAB11189-100UL In Stock 100ul €258.70
EAB11189-200UL In Stock 200ul €440.70
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Product Information
Applications WB, IF/ICC, ELISA
Species Reactivity Human, Mouse, Rat
Host / Isotype Rabbit IgG
Clonality Polyclonal
Applications Dilutions WB=1:500-2000¡¡
IF/ICC=1:50-300
MW (kDa) 46
Conjugate Unconjugate
Specificity NK-R1 Rabbit Polyclonal Antibody detects endogenous levels of NK-R1 protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20¡ãC least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4¡ãC for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin
IF
-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish
Hr
-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) Tachykinin receptor 1; Neurokinin-1 receptor; SPR; NK1R; NKIR; TAC1R; TACR1
Gene Aliases TACR1
UniProt ID

P25103

Entrez Gene ID

6869

Product Description

NK-1R also designated TACR1, NK1R, SPR, Substance-P Receptor, NK-1 Receptor, TAC1R, NKIR, or neurokinin 1 receptor is a member of a class of tachykinin receptors which also includes the NK-2 receptor and the NK-3 receptor. Substance P receptors bind to tachykinin peptides, including substance P, substance K and neuromedin K. NK-1R is likely to be involved in nociceptive transmission, basal ganglia function or anxiety and depression. NK-1R is expressed in a high proportion of spinothalmic and spinobranchial neurons located in lamina 1. NK-1R neurons in the dorsal horn of the spinal cord may play a role in chronic neuropathic and inflammatory pain. Ligand-induced internalization of NK-1R into early endosomes deplete the cell surface of these receptors. This internalization may be involved in a down-regulation response of a cell to substance P. 

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Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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