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Malic Enzyme 2/ME2 Mouse Monoclonal antibody
Catalog #:EAB22553
  SKU-Pack Size Availability Size Price
EAB22553-100UL In Stock 100ul $343.50
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Product Information
Applications WB, IHC-P
Species Reactivity Human, Mouse
Host / Isotype Mouse IgG1
Clonality Monoclonal
Applications Dilutions WB=1:1000-5000 
IHC-P=1:100-500
MW (kDa) 65
Conjugate Unconjugate
Specificity Malic Enzyme 2/ME2 Mouse Monoclonal Antibody detects endogenous levels of Malic Enzyme 2/ME2 protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin
IF
-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish
Hr
-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) Malic enzyme 2; ODS1; ME2
Gene Aliases ME2
UniProt ID

P23368

Entrez Gene ID

4200

Product Description

Malic enzyme 2(ME2) is a mitochondrial NAD-dependent malic enzyme. Found as a homotetramer, the main function of ME2 is to catalyze the anaplerotic reaction yielding pyruvate from (s)-malate. One single-nucleotide polymorphism of the ME2 gene has been associated with a phenotype manifested as psychosis. ME2 directly interacts with the malate shuttle system and has roles in neuronal synthesis of glutamate and gamma-amino butyric acid. This system has been shown to be altered in schizophrenia and bipolar disorder, which is also characterized by forms of epilepsy brought on by the role ME2 on ion channels in the brain.  

Product Image Gallery
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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