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Legumain Mouse Monoclonal Antibody
Catalog #:EAB22693
  SKU-Pack Size Availability Size Price
EAB22693-100UL In Stock 100ul $388.50
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Product Information
Applications WB, IHC-P, IF/ICC
Species Reactivity Human, Mouse, Pig
Host / Isotype Mouse IgG1
Clonality Monoclonal
Applications Dilutions WB=1:5000-20000 
IHC-P=1:100-500 
IF/ICC=1:100-500
MW (kDa) 49
Conjugate Unconjugate
Specificity Legumain Mouse Monoclonal Antibody detects endogenous levels of Legumain protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin
IF
-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish
Hr
-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) Legumain; AEP; LGMN1; PRSC1
Gene Aliases LGMN
UniProt ID

Q99538

Entrez Gene ID

5641

Product Description

Legumain also known as LGMN, AEP or PRSC1, is a 433 amino acid protein that localizes to the lysosome and belongs to the peptidase C13 family. Expressed ubiquitously with particularly high expression in placenta, heart and kidney, Legumain functions as a cysteine protease that specifically catalyzes the hydrolysis of asparaginyl and aspartyl bonds. Additionally, Legumain is thought to be involved in the processing of bacterial proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Legumain exists as both a precursor and a fully mature, active enzyme that is produced in dendritic cells. Overexpression of Legumain may be associated with the formation of solid tumors, suggesting a role for Legumain in carcinogenesis. Multiple isoforms of Legumain exist due to alternative splicing events.  

Product Image Gallery
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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