LIS1 also known as PAFAH1B1 plays a critical role in neuronal migration during brain development, and proper function is essential for the formation of a normal cerebral cortex. Mutations in LIS1 can lead to lissencephaly, a condition characterized by a smooth brain surface and severe cognitive impairments. LIS1 is primarily localized in the cytoplasm and interacts with doublecortin, another protein implicated in neuronal migration. This interaction is vital for the regulation of microtubule dynamics, which are crucial for the movement of neurons to their appropriate locations in the developing brain.