Q4VCS5

Angiomotin, also known as AMOT, is a 1,084 amino acid protein that belongs to the motin family of angiostatin binding proteins. Members of the motin family contain conserved coiled-coil domains and PDZ binding motifs at their C-termini. Expressed in skeletal muscle and placenta, Angiomotin localizes to the cell surface at tight junctions and is believed to be involved in tight junction maintenance. Angiomotin binds to angiostatin and plays a vital role in angiogenesis, promoting tubule formation and growth factor-induced migration of endothelial cells. This suggests that Angiomotin may be an important player in tumor angiogenesis and could serve as a potential therapeutic target in cancer.