Q9NPI1

BRD7 (bromodomain containing protein 7), also known as BP75 (75 kDa bromodomain protein), NAG4 or CELTIX1, is a 651 amino acid transcription regulation factor that contains one bromodomain and is expressed in liver, pancreas, intestines, kidney and cerebellum. Localizing to the nucleus, BRD7 plays an important role in cell cycle progression, signal-dependent gene expression and cell growth. BRD7 functions as a tumor suppressor, as is suggested by its apparent suppressive role on nasopharyngeal carcinoma (NPC) cell growth when overexpressed. Specifically, BRD7 negatively regulates the expression of cell cycle related proteins such as cyclin D1 and E2F-3, thereby inhibiting the G1-S progression. BRD7 also interacts with the centrosome associated protein BLOS2 and this BRD7-BLOS2 interaction inhibits the transcriptional suppression activity of BRD7 on various target genes.