TEX264(Testis expressed 264) also known as ZSIG11 is a 313 amino acid secreted protein primarily expressed in the testis, with its gene located on chromosome 3. Notably, TEX264 has been found to be upregulated in sporadic Parkinson′s disease, a neurodegenerative disorder characterized by symptoms such as rigidity, resting tremor, and bradykinesia. The upregulation of TEX264 in this context suggests potential involvement in critical biological processes associated with the disease, including cell cycle regulation, transcription, and inflammation. TEX264 interacts with specific proteins that play essential roles in cellular signaling and stress responses, highlighting importance in maintaining cellular homeostasis and potentially influencing neurodegenerative pathways.