SKU-Pack Size | Availability | Size | Price | |
EAB11102-30UL | In Stock | 30ul | €115.70 | |
EAB11102-100UL | In Stock | 100ul | €258.70 | |
EAB11102-200UL | In Stock | 200ul | €440.70 |
Please select the country you are in to find your local distributor. |
Betaclonal | Phone£º+34 (0)91 471 6763 | |
29/1 Lomonosovsky Pr, | E-mail£ºtech@betaclonal.com | |
Spain | Madrid, Spain | Web£ºwww.betaclonal.com |
Product Information | |
Applications | WB, IHC-P, IF/ICC, ELISA |
Species Reactivity | Human, Mouse, Rat |
Host / Isotype | Rabbit IgG |
Clonality | Polyclonal |
Applications Dilutions | WB=1:500-2000¡¡ IHC-P=1:50-300¡¡ IF/ICC=1:50-300 |
MW (kDa) | 183 |
Conjugate | Unconjugate |
Specificity | MADD Rabbit Polyclonal Antibody detects endogenous levels of MADD protein. |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20¡ãC least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4¡ãC for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
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Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
Product Bioinformatics | |
Synonym(s) | DENN; IG20; DEEAH; RabGEF; NEDDISH; RAB3GEP |
Gene Aliases | MADD |
UniProt ID | |
Entrez Gene ID |
Product Description | |
MADD belongs to the DENN family. MADD plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction. Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. |
Product Image Gallery | |
Western blot analysis of extracts on different cells, using MADD Rabbit Polyclonal Antibody (EAB11102) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Lane1: Hela Lane2: Jurkat Lane3: HepG2 Immunohistochemistry analysis of paraffin-embedded Human brain tissue, using MADD Rabbit Polyclonal Antibody (EAB11102) at 1:100 dilution.
Immunofluorescence analysis of A549 cell, using MADD Rabbit Polyclonal Antibody (EAB11102) at 1:200 dilution.
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Specific Protocols | |