GSDME(Gasdermin E) also known as DFNA5 is a 496 amino acid protein that is expressed in cochlea tissue, as well as in placenta, brain, heart, liver, lung and pancreas. GSDME plays a crucial role in auditory function; mutations in the gene encoding GSDME are associated with non-syndromic sensorineural deafness autosomal dominant type 5, a condition that leads to hearing loss due to damage in the auditory pathways of the brain. GSDME is located on human chromosome 7, which contains over 1,000 genes and accounts for nearly 5% of the human genome. Notably, defects in other genes on chromosome 7 have been implicated in various genetic disorders, including Osteogenesis imperfecta and Williams-Beuren syndrome, highlighting the critical nature of this chromosomal region in human health.