Q92918

HPK1 also known as MAP4K1 is a crucial serine/threonine kinase that plays a significant role in the regulation of the stress-responsive JNK/SAPK signaling pathway, which is vital for cellular responses to stress and inflammation. Located primarily in the cytoplasm, HPK1 interacts with various signaling molecules, including MEKK, to modulate the activity of downstream kinases, thereby influencing cellular processes such as apoptosis, differentiation, and proliferation. The proper functioning of HPK1 is essential for maintaining cellular homeostasis and responding to external stimuli, making HPK1 a key player in various physiological and pathological conditions. With an ability to activate the JNK signaling pathway, HPK1 is implicated in numerous diseases, including cancer and autoimmune disorders, highlighting the importance of studying HPK1 for therapeutic interventions.