Q92508

PIEZO1 also known as FAM38A, has recently been identified as a mechanotransduction protein that gets involved in mechanosensation and stretch-activated cation channel activation. PIEZO1 also plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER. Mutations in the gene encoding PIEZO1 are associated with hereditary xerocytosis. PIEZO1 also regulates extrusion to maintain homeostatic epithelial cell numbers.