Polyclonal Antibodies - SOCS2 Rabbit Polyclonal Antibody

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SOCS2 Rabbit Polyclonal Antibody

Catalog #：EAB11076

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB11076-30UL	In Stock	30ul	€115.70
EAB11076-100UL	In Stock	100ul	€258.70
EAB11076-200UL	In Stock	200ul	€440.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	Dianost	Phone：+49 (0) 40 65472-053
	Bullenkoppel 11， 23896 Poggensee,	E-mail：ola@olasciences.com
Germany	Germany	Web：www.olasciences.com

Product Information
Applications	WB, IHC-P, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-300
MW (kDa)	22
Conjugate	Unconjugate
Specificity	SOCS2 Rabbit Polyclonal Antibody detects endogenous levels of SOCS2 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Suppressor of cytokine signaling 2; CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2; SOCS2
Gene Aliases	SOCS2
UniProt ID	O14508
Entrez Gene ID	8835

Product Description

SOCS2(Suppressor of cytokine signaling 2) is a member of the suppressor of cytokine signaling (SOCS) family. SSOCS2 is widely expressed in adult and fetal tissues and is induced upon cytokine treatment. A number of studies suggest that SOCS2 can have either a positive or negative effect on GH/cytokine signaling. Mice deficient in SOCS2 grow signficantly larger than normal littermates. SOCS2 binds to tyrosine-phosphorylated GH and IGF-1 receptors via its SH2 domain, suppressing their signaling. In addition, the SOCS box of SOCS2 binds to Elongin B and C leading to activity as a ubiquitin ligase, promoting the degradation of the receptors as well as other SOCS family members.

Product Image Gallery
Western blot analysis of extracts on Hela, Jurkat cells, using SOCS2 Rabbit Polyclonal Antibody (EAB11076) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution. Immunohistochemical analysis of paraffin-embedded Human liver tissue, using SOCS2 Rabbit Polyclonal Antibody (EAB11076) at 1:200 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol