CLIP170 also known as CLIP1 is the original member of a group of microtuble binding proteins. CLIP170 plays a crucial role in cellular dynamics as a member of the plus-end-binding proteins (+TIPs), which are essential for microtubule stabilization and organization. By binding to the growing plus ends of microtubules, CLIP170 acts as a linker between these dynamic structures and organelle membranes, thereby promoting microtubule rescue and preventing catastrophe, particularly near the cell periphery. This function is vital for maintaining cellular integrity and facilitating intracellular transport, as CLIP170 ensures that microtubules remain stable and functional during cellular processes such as mitosis and organelle movement.