Monoclonal Antibodies - Bcl-10 Mouse Monoclonal antibody

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Bcl-10 Mouse Monoclonal antibody

Catalog #：EAB22205

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB22205-100UL	In Stock	100ul	￡218.90

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email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IHC-P, IF/ICC, FC, ELISA
Species Reactivity	Human, Mouse
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:100-500　 IF/ICC=1:100-500　 FC=1:50-200
MW (kDa)	26
Conjugate	Unconjugate
Specificity	Bcl-10 Mouse Monoclonal antibody detects endogenous levels of Bcl-10 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	BCL10 immune signaling adaptor; CLAP; mE10; CIPER; IMD37; c-E10; CARMEN; BCL10
Gene Aliases	BCL10
UniProt ID	O95999
Entrez Gene ID	8915

Product Description

Bcl-10 also known as CIPER, c-CARMEN, mE10 was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. Bcl-10 plays a crucial role in immune signaling and was initially identified as a gene that is truncated or mutated in MALT B cell lymphomas and other tumor types. Bcl-10 structure features an N-terminal caspase recruitment domain (CARD), which is essential for function in activating the NFκB signaling pathway via a NIK-dependent mechanism. This activation is significant as NFκB is a key regulator of immune responses and cell survival, making Bcl-10 a vital component in the modulation of apoptosis and inflammation. Furthermore, Bcl-10 has been implicated in the processing of caspase-9 to its active dimer, highlighting importance in apoptotic signaling.

Product Image Gallery

Western blot analysis of extracts on Hela, MCF7, Jurkat, NIH/3T3 cells, using Bcl-10 Mouse Monoclonal antibody (EAB22205) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.

Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue, using Bcl-10 Mouse Monoclonal antibody (EAB22205) at 1:200 dilution.

Immunohistochemical analysis of paraffin-embedded Human liver tissue, using Bcl-10 Mouse Monoclonal antibody (EAB22205) at 1:200 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol