CRMP-3 also known as DRP-4, DPYSL4 is a cytosolic phosphoprotein in the CRMP family that links extracellular guidance cues to microtubule dynamics and cytoskeletal remodeling. CRMP-3 has been implicated in neurite outgrowth, axon guidance, and regulation of cellular morphology through signaling pathways downstream of semaphorins and related kinases that modulate CRMP phosphorylation states. Beyond neural contexts, CRMP-3 expression has been associated with stress-adaptive programs and metabolic rewiring, connecting it to processes such as mitochondrial function, motility, and cell survival. Dysregulated CRMP-3 signaling has been reported in studies of neurological disorders and cancer-associated phenotypes, supporting its utility as a mechanistic target for pathway interrogation.