Monoclonal Antibodies - Brm Mouse Monoclonal Antibody

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Brm Mouse Monoclonal Antibody

Catalog #：EAB22281

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB22281-100UL	In Stock	100ul	€258.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

Please select the country you are in to find your local distributor.

	Cambiotech	Phone：+44 (0) 188 448801
	Lanwades Business Park,	E-mail：info@cambiotech.com
Ireland	Kobenhavn K, Ireland	Web：www.cambiotech.com

Product Information
Applications	WB, IHC-P, IF/ICC, FC, ELISA
Species Reactivity	Human
Host / Isotype	Mouse IgG1
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:100-500　 IF/ICC=1:50-200　 FC=1:50-200
MW (kDa)	181
Conjugate	Unconjugate
Specificity	Brm Mouse Monoclonal Antibody detects endogenous levels of Brm protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2; BIS; BRM; SNF2; SWI2; hBRM; NCBRS; Sth1p; BAF190; SNF2L2; SNF2LA; hSNF2a; SAMRCA2; SMARCA2
Gene Aliases	SMARCA2
UniProt ID	P51531
Entrez Gene ID	6595

Product Description

Brm also designated SMARCA2 is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Brm plays a crucial role in gene regulation. Brm functions as a transcriptional activator of Hox genes, interacting with nearly all transcriptionally active chromatin while maintaining a non-overlapping pattern with Polycomb, a known repressor of Hox gene transcription. This unique interaction is vital for proper expression of homeotic genes, as the Brm complex acts as an essential coactivator for the trithorax group protein Zeste, which binds to DNA and activates these genes. Notably, a reduction in Brm function significantly decreases the association of RNA polymerase II with Drosophila salivary gland chromosomes, indicating that chromatin remodeling activity of the Brm complex is fundamental for facilitating transcription by RNA polymerase II.

Product Image Gallery
Western blot analysis of extracts on Hela, HEK293, HepG2, A431 cells, using Brm Mouse Monoclonal Antibody (EAB22281) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution. Immunohistochemical analysis of paraffin-embedded Human rectal cancer tissue, using Brm Mouse Monoclonal Antibody (EAB22281) at 1:200 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol