Polyclonal Antibodies - RUNX3/AML2 Rabbit Polyclonal Antibody

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RUNX3/AML2 Rabbit Polyclonal Antibody

Catalog #：EAB11417

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB11417-30UL	In Stock	30ul	$133.50
EAB11417-100UL	In Stock	100ul	$298.50
EAB11417-200UL	In Stock	200ul	$508.50

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	EbioCell	Phone：(540) 808-3925
	Imperial Business Park 4819 Emperor Boulevard,	E-mail：order@ebiocell.com
United States	Suite 408 Durham, NC 27703, USA	Web：www.ebiocell.com

Product Information
Applications	WB, ELISA
Species Reactivity	Human, Mouse
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000
MW (kDa)	44
Conjugate	Unconjugate
Specificity	RUNX3/AML2 Rabbit Polyclonal Antibody detects endogenous levels of RUNX3/AML2 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	RUNX family transcription factor 3; Acute myeloid leukemia 2; AML2; CBFA3; PEBP2aC; RUNX3
Gene Aliases	RUNX3
UniProt ID	Q13761
Entrez Gene ID	864

Product Description

RUNX3 aslo known as AML2 is a member of the runt domain-containing family of transcription factors. RUNX3 plays a crucial role in regulating gene expression related to cellular differentiation and cell cycle progression. RUNX3 is predominantly expressed in hematopoietic cells, including myeloid and B-cell lines, as well as in the spleen. RUNX3 is involved in the growth and differentiation of gastric epithelial cells, positioning RUNX3 as a significant candidate for gastric cancer tumor suppression. RUNX3 function is particularly important because hypermethylation of the RUNX3 gene can lead to inactivation, which has been implicated in the development of gastric cancer. Detection of hypermethylation within the RUNX3 CpG island can serve as a valuable biomarker for diagnosing and assessing the risk of gastric cancer, highlighting RUNX3′s importance in both cancer biology and potential therapeutic strategies.

Product Image Gallery
Western blot analysis of extracts on HuvEc cells, using RUNX3/AML2 Rabbit Polyclonal Antibody (EAB11417) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol