MPTP hydrochloride
(CAS: 23007-85-4) |
SKU-Pack Size | Availability | Size | Price | |
EBC51160-10MG | In Stock | 10mg | ¥590.00 | |
EBC51160-50MG | In Stock | 50mg | ¥1690.00 | |
EBC51160-100MG | In Stock | 100mg | ¥2290.00 | |
EBC51160-1G | In Stock | 1g | ¥6390.00 |
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北京美瑞克生物科技有限公司 | Phone: +86 010-62890160 / 13691184142(微信同号) |
2 / F, 128 malianwa North Road, Haidian District, | E-mail: mrkbio@163.com | |
China | Beijing China | Website: www.mrkbio.com |
Product Information | |||||||||||||||||||||
Synonym(s) | MPTP hydrochloride; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride; MPTP | ||||||||||||||||||||
Chemical Name | 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine;hydrochloride | ||||||||||||||||||||
Application | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride is a Dopaminergic neurotoxin precursor of MPP+, widely used in research to study Parkinson′s disease | ||||||||||||||||||||
CAS Number | 23007-85-4 | ||||||||||||||||||||
Purity | ≥98.0% | ||||||||||||||||||||
Molecular Weight | 209.71 | ||||||||||||||||||||
Molecular Formula | C12H16ClN | ||||||||||||||||||||
SMILES | Cl.CN1CCC(=CC1)C1=CC=CC=C1 | ||||||||||||||||||||
Solubility | DMSO: 18.0 mg/mL (85.8 mM)
Ethanol: 40.0 mg/mL (190.7 mM) Water: 39.0 mg/mL (186.0 mM) |
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Preparing Stock Solutions |
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Shipping | Gel Pack | ||||||||||||||||||||
Storage | Store at -20°C | ||||||||||||||||||||
Research Use | For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use. |
Product Description | |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride (MPTP-HCl) is a dopaminergic neurotoxin that causes permanent symptoms of Parkinson′s disease by killing certain neurons in the substantia nigra of the brain. For this reason, it can be useful in the study of Parkinson′s disease. Specifically, it acts by targeting the mitochondria of neurons, where it is converted to 1-methyl-4-phenylpyridinium (MPP+). MPP+ is the active neurotoxin and inhibits mitochondrial complex I, leading to oxidative stress and neuronal death. In addition, MPTP-HCl affects dopamine metabolism and induces the release of glutamate. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloride is also known as MPTP hydrochloride and Dopaminergic neurotoxin. |
Specific Protocols | |