SKU-Pack Size | Availability | Size | Price | |
EAB11284-100UL | In Stock | 100ul | €258.70 |
Please select the country you are in to find your local distributor. |
SBT BioChem Srl | Phone£º+39 05 7156 8147 | |
Via Ponte di Bagnolo, 811 Bologna, | E-mail£ºinfo@sbtbiochem.it | |
Italy | Italy | Web£ºwww.sbtbiochem.it |
Product Information | |
Applications | WB |
Species Reactivity | Human, Mouse |
Host / Isotype | Rabbit IgG |
Clonality | Polyclonal |
Applications Dilutions | WB=1:500-2000 |
MW (kDa) | 141 |
Conjugate | Unconjugate |
Specificity | BRIP1 Rabbit Polyclonal Antibody detects endogenous levels of BRIP1 protein. |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20¡ãC least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4¡ãC for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
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Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
Product Bioinformatics | |
Synonym(s) | BACH-1; BRAC 1 Associated C Terminal Helicase 1; BACH1; BRIP1; FANCJ; OF; BRIP-1 |
Gene Aliases | BRIP1 |
UniProt ID | |
Entrez Gene ID |
Product Description | |
BRIP1 is ubiquitously expressed with highest levels in testis, an expression pattern similar to that of BRCA1. BRIP1 binds directly to the BRCT repeats of BRCA1 and the BRIP1-BRCA1 complex formation contributes to a key BRCA1 activity. BRIP1 is required to resolve the secondary structures of guanine-rich DNA that occasionally form during lagging-strand DNA synthesis. Phosphorylated BRIP1/BACH1 binds directly to the BRCT domain of BRCA1. This interaction is dependent on the phosphorylation of BRIP1/BACH1 at Ser 990, and is required for DNA damage-induced checkpoint control during the G2 to M phase transition of the cell cycle. |
Product Image Gallery | |
Western blot analysis of extracts on different cells, using BRIP1 Rabbit Polyclonal Antibody (EAB11284) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Lane1: MCF7 Lane2: Jurkat |
Specific Protocols | |