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BRIP1 Rabbit Polyclonal Antibody
Catalog #£ºEAB11284
  SKU-Pack Size Availability Size Price
EAB11284-100UL In Stock 100ul €258.70
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Product Information
Applications WB
Species Reactivity Human, Mouse
Host / Isotype Rabbit IgG
Clonality Polyclonal
Applications Dilutions WB=1:500-2000
MW (kDa) 141
Conjugate Unconjugate
Specificity BRIP1 Rabbit Polyclonal Antibody detects endogenous levels of BRIP1 protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20¡ãC least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4¡ãC for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin
IF
-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish
Hr
-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) BACH-1; BRAC 1 Associated C Terminal Helicase 1; BACH1; BRIP1; FANCJ; OF; BRIP-1
Gene Aliases BRIP1
UniProt ID

Q9BX63

Entrez Gene ID

83990

Product Description

BRIP1 is ubiquitously expressed with highest levels in testis, an expression pattern similar to that of BRCA1. BRIP1 binds directly to the BRCT repeats of BRCA1 and the BRIP1-BRCA1 complex formation contributes to a key BRCA1 activity. BRIP1 is required to resolve the secondary structures of guanine-rich DNA that occasionally form during lagging-strand DNA synthesis. Phosphorylated BRIP1/BACH1 binds directly to the BRCT domain of BRCA1. This interaction is dependent on the phosphorylation of BRIP1/BACH1 at Ser 990, and is required for DNA damage-induced checkpoint control during the G2 to M phase transition of the cell cycle. 

Product Image Gallery
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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