Q14246 Human

Q61549 Mouse

F4/80 also known as EMR1, ADGRE1 is a member of the epidermal growth factor (EGF)-TM7 family of G-protein coupled receptors, characterized by extended extracellular regions containing multiple EGF-like domains. F4/80 protein is exclusively expressed on macrophage surfaces, serving as a critical marker for mature macrophage populations in various tissues, including Kupffer cells in the liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin. F4/80 expression on macrophages is vital for understanding immune responses, playing a role in identifying and characterizing these immune cells in both health and disease. F4/80/EMR1 undergoes significant post-translational modifications, including extensive N-linked glycosylation and some O-linked glycosylation, which may influence macrophage adhesion, migration, and signaling pathways.