O96013

PAK4 is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell motility, proliferation, and survival, making PAK4 an important target for understanding cancer progression and metastasis. PAK4 is primarily located in the cytoplasm and translocates to the Golgi apparatus upon activation, where PAK4 interacts with polymerized actin clusters and beta coat proteins, highlighting PAK4′s involvement in cytoskeletal dynamics and intracellular signaling. PAK4′s interaction with GTP-bound CDC42 and ability to phosphorylate downstream substrates, such as MEK kinase, underscore PAK4′s significance in the JNK signaling pathway, which is vital for cellular responses to stress and growth factors. The gene encoding PAK4 is located on human chromosome 19, and PAK4 expression is notably high in tissues such as the prostate, testis, and colon, indicating PAK4′s potential role in tissue-specific functions and disease states.