P62140

PP1β also known as PP1beta, PPP1CB is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1β is a pivotal catalytic subunit within the Protein Phosphatase 1 (PP1) family, characterized by its conserved catalytic domain essential for serine/threonine phosphatase activity and a unique C-terminal region that mediates interactions with regulatory and targeting proteins. Post-translational modifications (PTMs) of PP1β, such as phosphorylation, methylation, and ubiquitination, play critical roles in modulating activity, stability, and subcellular localization, thereby fine-tuning involvement in key cellular processes including cell cycle regulation, metabolism, and apoptosis. Phosphorylation of PP1β can alter enzymatic activity and influence binding affinity to regulatory subunits, thereby impacting ability to dephosphorylate specific substrates. Methylation and ubiquitination further regulate PP1β by affecting interactions with other proteins and degradation via the proteasome pathway, respectively.