P11802

CDK4 is a vital member of the cyclin-dependent kinase family, playing a crucial role in regulating cell cycle progression by partnering with D-type cyclins to control cell growth during the G1 phase. The function of CDK4 is essential for the phosphorylation of key substrates that drive the cell cycle forward, making CDK4 a significant focus in cancer research and studies of cellular proliferation. The activity of CDK4 is modulated through interaction with cyclins, which enhance kinase activity, and inhibitors like p16, which suppress function. Additionally, the activation of CDK4-cyclin complexes involves phosphorylation by Cdk-activating proteins (CAK), highlighting the sophisticated regulatory mechanisms governing cell cycle progression.