PARG(Poly(ADP-ribose) glycohydrolase) is the enzyme responsible for polymer turnover. PARG protein plays a crucial role in cellular response to DNA damage by regulating turnover of poly(ADP-ribose) polymers, which are synthesized by poly(ADP-ribose) polymerase (PARP-1) and other related enzymes. This reversible covalent modification is essential for repair of damaged DNA, as PARG helps modulate activity of chromosomal proteins involved in repair process. Under normal growth conditions, PARG is predominantly localized in cytoplasm and is enzymatically active, undergoing cleavage during apoptosis induced by agents such as etoposide, staurosporine, and Fas. This cleavage generates two C-terminal fragments that retain active site necessary for hydrolyzing poly(ADP-ribose).